Endocrine Abstracts

Introduction: Sheehan syndrome represents a rare cause of hypopituitarism. It results from postpartum ischemic necrosis of the pituitary gland. Data evaluating the quality of life in women with Sheehan syndrome are scarce. The aim of this study was to assess the quality of life in patients with Sheehan syndrome and to determine its associated factors.Methods: A cross-sectional study including women with Sheehan syndrome was conducted in the department of...

Introduction: Pallister-Hall syndrome (PHS) is a very rare congenital syndrome, and its exact prevalence is still unknown. The clinical diagnosis is usually made when a hypothalamic hamartoma is associated with polydactyly. Endocrine manifestations consist of hypopituitarism, hypopituitarism, which can affect one or more pituitary axes, and precocious puberty. Here, we report the case of an 18-year-old young man in whom the diagnosis of PHS was delayed until his hospitalizatio...

Introduction: The clinical presentation of a secretory pituitary macroadenoma usually consists of a tumor syndrome accompanied by visual disturbances with signs of pituitary insufficiency and/or hormonal hypersecretion. Herein we describe an unusual presentation of a mixed secretory adenoma.Observation: A 69-year-old was referred to our department for the management of a pituitary macroadenoma revealed by a symptomatology mimicking the Hakim Adams triad ...

Introduction: Poorly controlled hypothyroidism is a chronic disease frequently associated with an impaired quality of life (QoL). However, persistent symptoms may be observed in well-controlled hypothyroid patients, impacting their QoL. The aim of our study was to assess the QoL in patients with well-controlled primary hypothyroidism and to evaluate the relationship between the TSH level and the QoL.Methods: A cross-sectional study was conducted in the o...

Introduction: Factitious hypoglycaemia in adults is usually due to exogenous intake of insulin or hypoglycaemia sulfonamides. This occult intake is most often voluntary and the diagnosis is not always obvious.Observation: We report the case of a 37-year-old pregnant woman at 15 weeks of amenorrhoea, followed for addisson’s disease since 3 years and not diabetic, was referred to our department for acute adrenal insufficiency following the discontinua...

Introduction: Metformin is the first-line treatment of type 2 diabetes mellitus. Poor adherence can be lead to poor glycemic control. The aim of our study was to determine the level of metformin adherence and its link with glycemic control in type 2 diabetic patients.Methods: We performed a cross-sectional study including 273 patients with type 2 diabetes taking metformin for at least three years. We assessed metformin adherence using the Girerd question...

Introduction: Insulin allergy is a clinical challenge in the management of type 1 diabetes mellitus since there is no other therapeutic alternative. The specific cause of insulin allergy can be related to insulin itself or to additives including zinc, protamine and meta-cresol. The manifestations range from localized reactions to systemic severe anaphylaxis. We here present the case of a generalized allergy to insulin excipient meta-cresol, in a type 1 diabetic patient success...

Plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenomas. Functioning ACTH-GH pituitary adenomas constitute an extremely rare entity. Most patients present a clinically manifested acromegaly and subclinical Cushing’s disease. We present the case of a 14 years old female who referred to the endocrinology department for inaugural diabetic ketosis. She had a six-month history of amenorrhea and headaches. On examination, she had facial dysmporph...

Introduction: Hemochromatosis is associated with iron overload that is responsible of iron deposit causing multiple organ dysfunctions which affects especially endocrine glands.Methods: We report four cases of pituitary hemochromatosis responsible of endocrine dysfunction. Results: Three women and one man were included, aged respectively 28, 19, 26 and 35 years old. These patients were suffering from ß-thalassemia and treated ...

Introduction: Non-functional pituitary adenomas (NFPAs) represent 30% of all pituitary adenomas and not associated with clinical evidence of hormonal hypersecretion. The aim of our study was to describe the clinical and paraclinical aspects of NFPAs.Methods: This is a retrospective descriptive study concerning 40 patients who were hospitalized in the endocrinology department of Rabta hospital in Tunis between January 2014 and December 2020. Clinical and ...